Pulmonary Lymphangioleiomyomatosis: A Case Report with Immunohistochemical Details and DNA Analysis

A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emp...

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Veröffentlicht in:	The Tohoku Journal of Experimental Medicine 2003, Vol.199(2), pp.119-126
Hauptverfasser:	Pan, Li-Hua, Ito, Harumasa, Kurose, Akira, Yamauchi, Kohei, Inoue, Hiroshi, Sawai, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis Antigens, Neoplasm Cell Division Desmin - biosynthesis DNA - genetics DNA - metabolism Female HMB45 Humans Hydrogen-Ion Concentration Immunohistochemistry Lung - pathology Lung - physiology Lymphangioleiomyomatosis - diagnosis Lymphangioleiomyomatosis - genetics Melanoma-Specific Antigens Middle Aged Muscle, Smooth - metabolism Neoplasm Proteins - biosynthesis Polymorphism, Single-Stranded Conformational pulmonary lymphangioleiomyomatosis Receptors, Estrogen - biosynthesis Receptors, Progesterone - biosynthesis Tomography, X-Ray Computed Tuberous Sclerosis - metabolism Vimentin - biosynthesis
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Zusammenfassung:	A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emphysema were main findings. Immunohistochemically, these proliferating spindle shaped cells were positive for α-smooth muscle actin, desmin, vimentin, HMB45, estrogen receptor and progesterone receptor, but negative for S-100, cytokeratin. Single strand conformation polymorphism (SSCP) and DNA analysis for tuberous sclerosis 1 and 2 showed no significant abnormality.
ISSN:	0040-8727 1349-3329
DOI:	10.1620/tjem.199.119