A bioassay for cobra cardiotoxin activity using semi-isolated cockroach heart

A semi-isolated cockroach heart preparation was used to rapidly determine the activity of cobra cardiotoxin, monitored as a direct response on heart rate. This preparation produced a dose-response curve in the presence of active cardiotoxin and demonstrated that cardiotoxin retained its biological a...

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Veröffentlicht in:	Toxicon (Oxford) 1992-03, Vol.30 (3), p.295-301
Hauptverfasser:	Klowden, Marc J., Vitale, Angelo J., Trumble, Mayme J., Wesson, Carla Ruder, Trumble, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Biological Assay Cobra Cardiotoxin Proteins - analysis Cobra Cardiotoxin Proteins - metabolism Cobra Cardiotoxin Proteins - pharmacology Cockroaches - drug effects Cross-Linking Reagents Heart Rate - drug effects Medical sciences Membrane Proteins - metabolism Molecular Weight Myocardium - metabolism Succinimides Toxicology
Online-Zugang:	Volltext
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