The first example of enantioselective isocyanosilylation of meso epoxides with TMSCN catalyzed by novel chiral organogallium and indium complexes

The first example of enantioselective isocyanosilylation of meso epoxides with TMSCN catalyzed by novel chiral organogallium and indium complexes

The desymmetrization ring opening of meso epoxides using trimethylsilyl cyanide catalyzed by organogallium and indium complexes with binaphthol monoether derivatives as chiral ligands gave beta-isocyanohydrins with moderate to excellent enantioselectivities of up to 95% ee.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2003-03 (6), p.692-693
Hauptverfasser: Zhu, Chengjian, Yuan, Fang, Gua, Weijin, Pan, Yi
Format: Artikel
Sprache:eng
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Zusammenfassung:The desymmetrization ring opening of meso epoxides using trimethylsilyl cyanide catalyzed by organogallium and indium complexes with binaphthol monoether derivatives as chiral ligands gave beta-isocyanohydrins with moderate to excellent enantioselectivities of up to 95% ee.
ISSN:1359-7345
DOI:10.1039/b212511k