Conformational analysis of the anomeric forms of kojibiose, nigerose, and maltose using MM3

Energy surfaces were computed for relative orientations of the relaxed pyranosyl rings of the two anomeric forms of kojibiose, nigerose, and maltose, the (1 → 2)-α, (1 → 3)-α- and (1 → 4)-α-linked d-glucosyl disaccharides, respectively. Twenty-four combinations of starting conformations of the rotat...

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Veröffentlicht in:Carbohydrate research 1992-06, Vol.230 (2), p.223-244
Hauptverfasser: Dowd, Michael K., Zeng, Jing, French, Alfred D., Reilly, Peter J.
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Sprache:eng
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Zusammenfassung:Energy surfaces were computed for relative orientations of the relaxed pyranosyl rings of the two anomeric forms of kojibiose, nigerose, and maltose, the (1 → 2)-α, (1 → 3)-α- and (1 → 4)-α-linked d-glucosyl disaccharides, respectively. Twenty-four combinations of starting conformations of the rotatable side-groups were considered for each disaccharide. Optimized structures were calculated using MM3 on a 20° grid spacing of the torsional angles about the glycosidic bonds. The energy surfaces of the six disaccharides were similar in many respects but differed in detail within the low-energy regions. The maps also illustrate the importance of the exo-anomeric effect and linkage type in determining the conformational flexibility of disaccharides. Torsional conformations of known crystal structures of maltosyl-containing molecules lie in a lower MM3 energy range than previously reported.
ISSN:0008-6215
1873-426X
DOI:10.1016/0008-6215(92)84035-Q