Infectious complications of biologic treatments of rheumatoid arthritis

Agents that block the action of tumor necrosis factor-α and recombinant interleukin-1 have been shown to be effective biologic treatment modalities in patients with rheumatoid arthritis. Given the immunosuppressive effects of tumor necrosis factor-α and interleukin-1 blockers, infections have emerge...

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Veröffentlicht in:Current opinion in rheumatology 2003-05, Vol.15 (3), p.179-184
Hauptverfasser: Mohan, Aparna K, Coté, Timothy R, Siegel, Jeffrey N, Braun, Miles M
Format: Artikel
Sprache:eng
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Zusammenfassung:Agents that block the action of tumor necrosis factor-α and recombinant interleukin-1 have been shown to be effective biologic treatment modalities in patients with rheumatoid arthritis. Given the immunosuppressive effects of tumor necrosis factor-α and interleukin-1 blockers, infections have emerged as possible complications of using these agents, an observation foreshadowed in prelicensure animal studies. At this time, hundreds of thousands of patients have received these drugs, and a wide variety of infectious complications has been reported, among which reactivation tuberculosis is most notable. Case reports alone, however, do not necessarily reflect a causal association between a therapeutic product and an adverse event. The authors review the infectious complications of the use of these agents as reported in the medical literature from November 2001 through October 2002.
ISSN:1040-8711
1531-6963
DOI:10.1097/00002281-200305000-00002