Homeostasis as Regulated by Activated Macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Fluor) against Acute Infection by Toxoplasma gondii in Mice

An oral administration of partially purified LPSw, a lipopolysaccharide (LPS) from wheat fluor, at a concentraion of 20 ng/ml in drinking water beginning 1 d after infection significantly decreased mouse mortality and prevented animal weight loss in acute infection with Toxoplasma gondii. Whereas 71...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/05/25, Vol.40(5), pp.1266-1267
Hauptverfasser:	SUZUKI, Yasuhiro, KOBAYASHI, Akio, NISHIZAWA, Takashi, INAGAWA, Hiroyuki, MORIKAWA, Akinobu, SOMA, Gen-Ichiro, MIZUNO, Den'ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Oral Animals Biological and medical sciences Female homeostasis Homeostasis - drug effects Homeostasis - physiology Immunomodulators lipopolysaccharide (LPS) Lipopolysaccharides - therapeutic use LPSw macrophage Macrophage Activation - drug effects Macrophage Activation - physiology Macrophages - drug effects Macrophages - physiology Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Toxoplasma Toxoplasma gondii toxoplasmosis Toxoplasmosis, Animal - drug therapy Toxoplasmosis, Animal - prevention & control Triticum Triticum aestivum
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Zusammenfassung:	An oral administration of partially purified LPSw, a lipopolysaccharide (LPS) from wheat fluor, at a concentraion of 20 ng/ml in drinking water beginning 1 d after infection significantly decreased mouse mortality and prevented animal weight loss in acute infection with Toxoplasma gondii. Whereas 71% (5/7) of mice in a control group that did not receive LPSw died of toxoplasmosis, only 14% (1/7) of mice treated with LPSw died (p
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.1266