Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal

Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal

A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for t...

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Veröffentlicht in:Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie Série III, Sciences de la vie, 1992, Vol.314 (13), p.573-578
Hauptverfasser: Dard, P, Schreiber, Y, Excoffier, L, Sanchez-Mazas, A, Shi-Isaac, X, Epelbouin, A, Langaney, A, Jeannet, M
Format: Artikel
Sprache:fre
Schlagworte:
Alleles
Chi-Square Distribution
Genes, MHC Class I - genetics
Heterozygote
HLA-A Antigens - genetics
HLA-B Antigens - genetics
HLA-C Antigens - genetics
Humans
Phenotype
Polymorphism, Genetic - genetics
Senegal - epidemiology
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Zusammenfassung:A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for the three loci A, B, and C are respectively 0.884, 0.944 and 0.829. The Mandenkalu allelic frequencies are close to that found in other sub-Saharan populations. They show, however, some peculiarities like the occurrence of the Bw 56 allele and the high frequencies of both B5 and B35.
ISSN:0764-4469