Physiologic weight-bearing increases new vessel formation during distraction osteogenesis: a micro-tomographic imaging study

During distraction osteogenesis, large volumes of new bone are formed through the slow distraction of fracture callus. The newly formed bone is closely linked to angiogenesis and positively influenced by physiologic loading. In this study, a rat model was used to explore the correlation between thes...

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Veröffentlicht in:	Journal of orthopaedic research 2003-05, Vol.21 (3), p.489-496
Hauptverfasser:	Moore, Douglas C, Leblanc, Christopher W, Müller, Ralph, Crisco, Joseph J, Ehrlich, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Bone lengthening Distraction osteogenesis Femur - diagnostic imaging Femur - physiology Femur - surgery Image Processing, Computer-Assisted Male Neovascularization, Physiologic - physiology Osteogenesis - physiology Osteogenesis, Distraction Physical stimulation Rats Rats, Sprague-Dawley Tomography, X-Ray Computed Weight-Bearing - physiology
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Zusammenfassung:	During distraction osteogenesis, large volumes of new bone are formed through the slow distraction of fracture callus. The newly formed bone is closely linked to angiogenesis and positively influenced by physiologic loading. In this study, a rat model was used to explore the correlation between these two observations. Unilateral femoral lengthenings were performed in 18 male Sprague–Dawley rats (400–500 g, age
ISSN:	0736-0266 1554-527X
DOI:	10.1016/S0736-0266(02)00234-6