Myocytes Die by Multiple Mechanisms in Failing Human Hearts

We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanismsapoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 patients with idiopathic dilated cardiomyopathy (EF≤20%) and 7 control hearts were analyzed. Myocyte apoptosis revealed by caspase-...

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Veröffentlicht in:	Circulation research 2003-04, Vol.92 (7), p.715-724
Hauptverfasser:	Kostin, Sawa, Pool, Lieven, Elsässer, Albrecht, Hein, Stefan, Drexler, Hannes C.A, Arnon, Eyal, Hayakawa, Yukihiro, Zimmermann, René, Bauer, Erwin, Klövekorn, Wolf-Peter, Schaper, Jutta
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Biological and medical sciences Blotting, Western Carbon-Nitrogen Lyases - metabolism Cardiology. Vascular system Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Cathepsin D - metabolism Cysteine Endopeptidases - metabolism Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans In Situ Nick-End Labeling Ligases - metabolism Medical sciences Microscopy, Confocal Microscopy, Immunoelectron Multienzyme Complexes - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Necrosis Proteasome Endopeptidase Complex Ubiquitin - metabolism Ubiquitin-Activating Enzymes Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases
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Zusammenfassung:	We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanismsapoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 patients with idiopathic dilated cardiomyopathy (EF≤20%) and 7 control hearts were analyzed. Myocyte apoptosis revealed by caspase-3 activation and TUNEL staining occurred at a rate of 0.002±0.0005% (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.0000067471.95890.5C