Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha

It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-alpha and IFN-gamma) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-gamma and tumour necrosis factor (TNF)-alpha trigger a partially overlapping set...

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Veröffentlicht in:	Journal of general virology 2003-05, Vol.84 (Pt 5), p.1253-1259
Hauptverfasser:	Frese, Michael, Barth, Kerstin, Kaul, Artur, Lohmann, Volker, Schwärzle, Verena, Bartenschlager, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Drug Resistance, Viral Hepacivirus - genetics Hepacivirus - pathogenicity Hepacivirus - physiology Hepatitis C virus Humans Interferon-gamma - pharmacology RNA, Viral - biosynthesis Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Virus Replication - drug effects
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