Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha

It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-alpha and IFN-gamma) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-gamma and tumour necrosis factor (TNF)-alpha trigger a partially overlapping set...

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Veröffentlicht in:Journal of general virology 2003-05, Vol.84 (Pt 5), p.1253-1259
Hauptverfasser: Frese, Michael, Barth, Kerstin, Kaul, Artur, Lohmann, Volker, Schwärzle, Verena, Bartenschlager, Ralf
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Sprache:eng
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Zusammenfassung:It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-alpha and IFN-gamma) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-gamma and tumour necrosis factor (TNF)-alpha trigger a partially overlapping set of antiviral defence mechanisms, it is tempting to speculate that TNF-alpha also inhibits HCV replication. However, this study shows that TNF-alpha does not affect HCV protein and RNA synthesis, nor does it synergistically enhance the inhibitory effect of IFN-gamma. Taken together, these results demonstrate that HCV replication in Huh-7 cells is highly resistant to TNF-alpha. It is, therefore, unlikely that the increased production of TNF-alpha, which is seen in many hepatitis C patients, contributes to HCV clearance by inducing antiviral defence mechanisms in infected hepatocytes.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.18997-0