Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)
A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous rou...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1992/04/25, Vol.40(4), pp.1004-1006 |
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| container_issue | 4 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 40 |
| creator | IGUCHI, Makoto INAGAWA, Hiroyuki NISHIZAWA, Takashi OKUTOMI, Takafumi MORIKAWA, Akinobu SOMA, Gen-Ichiro MIZUNO, Den'ichi |
| description | A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous route of administration is most favorable. The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed. |
| doi_str_mv | 10.1248/cpb.40.1004 |
| format | Article |
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The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.40.1004</identifier><identifier>PMID: 1525928</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Female ; Flour ; General and cellular metabolism. Vitamins ; homeostasis ; Homeostasis - physiology ; Humans ; lipopolysaccharide ; Lipopolysaccharides - administration & dosage ; macrophage ; Macrophage Activation - physiology ; Medical sciences ; Mice ; Mice, Inbred NOD ; non-obese diabetic mice ; Pharmacology. Drug treatments ; Triticum</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1992/04/25, Vol.40(4), pp.1004-1006</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4544-72bdfdace33044a7f5d7c815c4843e263f4ce74c7bd0061701e02b8688f0a4cb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5406420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1525928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IGUCHI, Makoto</creatorcontrib><creatorcontrib>INAGAWA, Hiroyuki</creatorcontrib><creatorcontrib>NISHIZAWA, Takashi</creatorcontrib><creatorcontrib>OKUTOMI, Takafumi</creatorcontrib><creatorcontrib>MORIKAWA, Akinobu</creatorcontrib><creatorcontrib>SOMA, Gen-Ichiro</creatorcontrib><creatorcontrib>MIZUNO, Den'ichi</creatorcontrib><title>Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous route of administration is most favorable. The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Female</subject><subject>Flour</subject><subject>General and cellular metabolism. Vitamins</subject><subject>homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>macrophage</subject><subject>Macrophage Activation - physiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>non-obese diabetic mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Triticum</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUhS0EKkNhxRrJC4RAKINjOxPPsuqDIs0AojyW0Y1zM-MqiYNvUjT_hp-KQ0btxr7W-XSPfA5jL1OxTKU2H2xfLnWchdCP2CJVOk8yKdVjthBCrBOpVuope0Z0K4TMRK5O2EmayWwtzYL9vfYtehqAHHEg_g13YwMDVrw88DM7uLv_jy3Y4Ps97HDJfy75zdj3AYmc77iv-YWDEgckvsWmccNI3HX8s-8SXyLhUXaWb53Fae_m680f_hb4xvW-982BwNo9BFchr4Nv-a89wsCvGj-Gd8_ZkxoawhfH-5T9uLr8fn6dbL58_HR-tkmszrROcllWdQUWlRJaQ15nVW5NmllttEK5UrW2mGubl5UQqzQXKQpZmpUxtQBtS3XK3sx7--B_j0hD0Tqy8T_QoR-pyFVqTLSK4PsZjIkQBayLPrgWwqFIRTH1UcQ-Ch3n2EekXx3XjmWL1QM7FxD110cdyEJTB-iso3ss02KlpYjYxYzdxqp2eK9DiLk2OFmm68xMtno-JvcHOaZbYKf-AYZnq40</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>IGUCHI, Makoto</creator><creator>INAGAWA, Hiroyuki</creator><creator>NISHIZAWA, Takashi</creator><creator>OKUTOMI, Takafumi</creator><creator>MORIKAWA, Akinobu</creator><creator>SOMA, Gen-Ichiro</creator><creator>MIZUNO, Den'ichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)</title><author>IGUCHI, Makoto ; INAGAWA, Hiroyuki ; NISHIZAWA, Takashi ; OKUTOMI, Takafumi ; MORIKAWA, Akinobu ; SOMA, Gen-Ichiro ; MIZUNO, Den'ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4544-72bdfdace33044a7f5d7c815c4843e263f4ce74c7bd0061701e02b8688f0a4cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Female</topic><topic>Flour</topic><topic>General and cellular metabolism. Vitamins</topic><topic>homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>macrophage</topic><topic>Macrophage Activation - physiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>non-obese diabetic mice</topic><topic>Pharmacology. 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V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1992</date><risdate>1992</risdate><volume>40</volume><issue>4</issue><spage>1004</spage><epage>1006</epage><pages>1004-1006</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous route of administration is most favorable. The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1525928</pmid><doi>10.1248/cpb.40.1004</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1992/04/25, Vol.40(4), pp.1004-1006 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences diabetes Diabetes Mellitus, Type 2 - drug therapy Female Flour General and cellular metabolism. Vitamins homeostasis Homeostasis - physiology Humans lipopolysaccharide Lipopolysaccharides - administration & dosage macrophage Macrophage Activation - physiology Medical sciences Mice Mice, Inbred NOD non-obese diabetic mice Pharmacology. Drug treatments Triticum |
| title | Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour) |
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