Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)

A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous rou...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/04/25, Vol.40(4), pp.1004-1006
Hauptverfasser:	IGUCHI, Makoto, INAGAWA, Hiroyuki, NISHIZAWA, Takashi, OKUTOMI, Takafumi, MORIKAWA, Akinobu, SOMA, Gen-Ichiro, MIZUNO, Den'ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences diabetes Diabetes Mellitus, Type 2 - drug therapy Female Flour General and cellular metabolism. Vitamins homeostasis Homeostasis - physiology Humans lipopolysaccharide Lipopolysaccharides - administration & dosage macrophage Macrophage Activation - physiology Medical sciences Mice Mice, Inbred NOD non-obese diabetic mice Pharmacology. Drug treatments Triticum
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Zusammenfassung:	A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous route of administration is most favorable. The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.1004