Rapid and reliable induction of partial status epilepticus in naive rats by low-frequency (3-Hz) stimulation of the amygdala

Rapid and reliable induction of partial status epilepticus in naive rats by low-frequency (3-Hz) stimulation of the amygdala

Naive rats were electrically stimulated in the amygdala with biphasic square wave pulses at 3 Hz in a model of partial status epilepticus (SE). This treatment led to the rapid kindling of seizures in all rats, and the subsequent induction of SE in 100% of rats stimulated for approximately 30–60 min....

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Veröffentlicht in:Epilepsy research 1992-06, Vol.12 (1), p.51-55
Hauptverfasser: Cain, D.Peter, McKitrick, Douglas J, Boon, Francis
Format: Artikel
Sprache:eng
Schlagworte:
Amygdala - physiopathology
Amygdala stimulation
Animals
Electric Stimulation
Kindling, Neurologic
Low-frequency stimulation
Male
Rat
Rats
Status epilepticus
Status Epilepticus - physiopathology
Time Factors
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Zusammenfassung:Naive rats were electrically stimulated in the amygdala with biphasic square wave pulses at 3 Hz in a model of partial status epilepticus (SE). This treatment led to the rapid kindling of seizures in all rats, and the subsequent induction of SE in 100% of rats stimulated for approximately 30–60 min. Extensive gliosis and degeneration was seen in the basal forebrain of the SE brains. This method of inducing SE is simpler, more rapid, and more reliable than similar methods reported previously.
ISSN:0920-1211
1872-6844
DOI:10.1016/0920-1211(92)90091-7