Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil

After inhalation experiments with sandalwood oil and the pure fragrance compounds coumarin and α‐terpineol, substances were detected and measured in the blood samples of test animals (mice) using gas chromatography/mass spectrometry (GC/MS) (MID) in connection with GC/FTIR (SWC), GC/AES (carbon and oxygen trace) and flame ionization detection/gas chromatography. Using tiglinic acid benzyl ester as the internal standard the following concentrations in serum could be found: α‐santalol 6.1 ng/mL, β‐santalol 5.3 ng/mL and α‐santalene 0.5 ng/mL. In separate inhalation experiments with coumarin and with α‐terpineol the corresponding concentrations were 7.7 ng/mL and 6.9 ng/mL, respectively.