Prognostic value of breast cancer aromatase

The estrogen receptor, progesterone receptor, and intratumoral aromatase content of 127 breast carcinomas were determined. Patients whose tumor contained either estrogen or progesterone receptors had a longer disease‐free interval, but no difference in survival was observed. Measurable aromatase act...

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Veröffentlicht in:	Cancer 1992-10, Vol.70 (7), p.1951-1955
Hauptverfasser:	Lipton, Allan, Santen, Richard J., Santner, Steven J., Harvey, Harold A., Sanders, Sherry I., Matthews, Yvonne L.
Format:	Artikel
Sprache:	eng
Schlagworte:	aromatase Aromatase - metabolism Biological and medical sciences breast cancer Breast Neoplasms - chemistry Breast Neoplasms - enzymology Breast Neoplasms - mortality Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Prognosis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Recurrence relapse survival Survival Analysis Tumors
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Zusammenfassung:	The estrogen receptor, progesterone receptor, and intratumoral aromatase content of 127 breast carcinomas were determined. Patients whose tumor contained either estrogen or progesterone receptors had a longer disease‐free interval, but no difference in survival was observed. Measurable aromatase activity was detected in 78 of 113 (69%) tumors. There was no relationship between aromatase activity and disease‐free interval or survival. Cancer 1992; 70:1951‐1955.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(19921001)70:7<1951::AID-CNCR2820700723>3.0.CO;2-#