Relationship between primary structure and activity in exorphins and endogenous opioid peptides

We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. Th...

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Veröffentlicht in:	FEBS letters 1992-09, Vol.310 (1), p.13-16
Hauptverfasser:	Ya. Bakalkin, Georgy, Demuth, Hans-Ulrich, Nyberg, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	activity Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences endorphins Endorphins - chemistry Endorphins - physiology exorphins Fundamental and applied biological sciences. Psychology Guinea Pigs Mice Molecular Sequence Data Opioid peptides Peptides - chemistry Peptides - physiology primary structure Primary structure-activity relationship Proteins Rats Structure-Activity Relationship
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Zusammenfassung:	We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. These segment pairs represent basic elements of the regulatory peptide primary structure pattern, which was found recently [Dokl. Akad. Nauk USSR 289 (1986) 721–724; Int. J. Peptide Prot. Res. 38 (1991) 505–510].
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(92)81135-9