DNA fuel for free-running nanomachines

DNA fuel for free-running nanomachines

We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive fre...

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Veröffentlicht in:Physical review letters 2003-03, Vol.90 (11), p.118102-118102, Article 118102
Hauptverfasser: Turberfield, A J, Mitchell, J C, Yurke, B, Mills, Jr, A P, Blakey, M I, Simmel, F C
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA - chemistry
DNA - metabolism
Kinetics
Nanotechnology - methods
Nucleic Acid Conformation
Nucleic Acid Hybridization
Oligonucleotides - chemistry
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Zusammenfassung:We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.90.118102