Inhibitory effect of human chorionic gonadotropin (hCG) on HIV-1 transmission from lymphocytes to trophoblasts

It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo, hCG - the major product of fetal trophoblasts - was tested on an in vitro model consisting of chori...

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Veröffentlicht in:	FEBS letters 1992-08, Vol.309 (1), p.82-84
Hauptverfasser:	Bourinbaiar, Aldar S., Nagorny, Raisa
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - pharmacology Biological and medical sciences Cell Line Chorionic Gonadotropin - pharmacology Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology hCG HIV HIV Core Protein p24 - analysis HIV-1 - drug effects HIV-1 - physiology Humans Lymphocyte Lymphocytes - microbiology Microbiology Placenta Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Trophoblast Trophoblasts - microbiology Virology Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo, hCG - the major product of fetal trophoblasts - was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose- effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(92)80744-2