Helper T-cell-regulated B-cell immunity

Helper T-cell-regulated B-cell immunity

Helper T-cell-regulated B-cell responses constitute a major component of the immune response to many pathogens. Spatially and temporally organized cognate intercellular communication within secondary lymphoid organs is the critical regulating event in this complex adaptive response to antigen. Here,...

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Veröffentlicht in:Microbes and infection 2003-03, Vol.5 (3), p.205-212
Hauptverfasser: McHeyzer-Williams, Michael, McHeyzer-Williams, Louise, Panus, Joanne, Pogue-Caley, Rebecca, Bikah, Gabriel, Driver, David, Eisenbraun, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Antigens, Differentiation, T-Lymphocyte
B lymphocytes
B-Lymphocytes - immunology
Gene Expression Regulation
Helper-inducer
Humans
Immunity, Active
Immunologic Memory
Subsets
T lymphocytes
T-Lymphocytes, Helper-Inducer - immunology
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Zusammenfassung:Helper T-cell-regulated B-cell responses constitute a major component of the immune response to many pathogens. Spatially and temporally organized cognate intercellular communication within secondary lymphoid organs is the critical regulating event in this complex adaptive response to antigen. Here, we discuss what is known of these molecular exchanges and their cellular consequences in a serial synapsis model of adaptive immunity.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(03)00012-1