Cholinesterase Inhibitory Constituents from Onosma hispida

Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2′-dihydroxy-7,4′,5′-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2′-dihydroxy-7,5′-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(4), pp.412-414
Hauptverfasser:	Ahmad, Ijaz, Anis, Itrat, Malik, Abdul, Nawaz, Sarfraz Ahmad, Choudhary, Muhammad Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Boraginaceae Butyrylcholinesterase - metabolism cholinesterase inhibitor Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology flavanone General pharmacology Horses Medical sciences Onosma hispida Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Structures
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Beschreibung
Zusammenfassung:	Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2′-dihydroxy-7,4′,5′-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2′-dihydroxy-7,5′-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.412