p53-related pathways and the molecular pathogenesis of melanoma

Cutaneous malignant melanoma (CMM) is a life-threatening cancer that can have a poor prognosis with high metastatic potential. Its incidence is rapidly increasing worldwide. Its molecular alterations involve multiple pathways, including those related to p53. Since 1981, more than 380 papers containi...

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Veröffentlicht in:	European journal of cancer prevention 2003-04, Vol.12 (2), p.93-100
Hauptverfasser:	Hussein, M R, Haemel, A K, Wood, G S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dermatology Disease Models, Animal Genes, p53 Humans Medical sciences Melanoma - physiopathology Mice Review Skin Neoplasms - physiopathology Tumors of the skin and soft tissue. Premalignant lesions Ultraviolet Rays - adverse effects
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Zusammenfassung:	Cutaneous malignant melanoma (CMM) is a life-threatening cancer that can have a poor prognosis with high metastatic potential. Its incidence is rapidly increasing worldwide. Its molecular alterations involve multiple pathways, including those related to p53. Since 1981, more than 380 papers containing the terms 'p53 and melanoma' as key words in the Abstract have been published in the literature. However, in spite of these extensive investigations, a review of p53 and associated genes in CMM is still lacking. To remedy this issue, this review seeks to provide a brief overview of p53 and discuss the genes targeted along its related pathways. European Journal of Cancer Prevention 12:93-100 © 2003 Lippincott Williams & Wilkins.
ISSN:	0959-8278 1473-5709
DOI:	10.1097/00008469-200304000-00002