Interference with ovulation and luteal function by human ovarian follicular fluid peptide in bonnet monkeys, Macaca radiata

Partially purified human ovarian follicular fluid peptide (hGF 2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF 2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by increased progesterone levels. In 4 out of 5 hGF 2-injected animals, plasma progesterone levels were drastically reduced. Plasma estradiol levels were decreased only in 3 animals in which amenorrhea was observed. These data reveal that hGF 2 injection disrupted ovarian function in bonnet monkeys.