Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

Claudins are transmembrane proteins that seal tight junctions, and are critical for maintaining cell-to-cell adhesion in epithelial cell sheets. However, their role in cancer progression remains largely unexplored. Here, we report that Claudin-7 (CLDN-7) expression is lower in invasive ductal carcin...

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Veröffentlicht in:	Oncogene 2003-04, Vol.22 (13), p.2021-2033
Hauptverfasser:	KOMINSKY, Scott L, ARGANI, Pedram, KORZ, Dorian, EVRON, Ella, RAMAN, Venu, GARRETT, Elizabeth, REIN, Alan, SAUTER, Guido, KALLIONIEMI, Olli-P, SUKUMAR, Saraswati
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast - cytology Breast - metabolism Breast cancer Breast carcinoma Breast Neoplasms - chemistry Breast Neoplasms - pathology Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - chemistry Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Lobular - chemistry Carcinoma, Lobular - pathology Cell adhesion Cell adhesion & migration Cell Adhesion - drug effects Cell culture Cells, Cultured - chemistry Cells, Cultured - drug effects Classical genetics, quantitative genetics, hybrids Claudins DNA Methylation Epithelial cells Epithelial Cells - chemistry Epithelium Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene Silencing Genetics of eukaryotes. Biological and molecular evolution Hepatocyte growth factor Hepatocyte Growth Factor - pharmacology Human Humans Invasiveness Medicine Membrane proteins Membrane Proteins - biosynthesis Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - physiology Neoplasm Invasiveness - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Neoplasm Proteins - physiology Polymerase Chain Reaction Promoter Regions, Genetic Proteins RNA, Messenger - analysis RNA, Neoplasm - analysis Sequence Analysis, DNA Severity of Illness Index Tight junctions Tight Junctions - chemistry Tumor cell lines Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - drug effects Tumors
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Zusammenfassung:	Claudins are transmembrane proteins that seal tight junctions, and are critical for maintaining cell-to-cell adhesion in epithelial cell sheets. However, their role in cancer progression remains largely unexplored. Here, we report that Claudin-7 (CLDN-7) expression is lower in invasive ductal carcinomas (IDC) of the breast than in normal breast epithelium, as determined by both RT-PCR (9/10) and Western analysis (6/8). Immunohistochemical (IHC) analysis of ductal carcinoma in situ (DCIS) and IDC showed that the loss of CLDN-7 expression correlated with histological grade in both DCIS (P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/sj.onc.1206199