Protein metal-binding sites

Protein metal-binding sites

Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins. Recent developments...

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Veröffentlicht in:Current opinion in biotechnology 1992, Vol.3 (4), p.378-387
Hauptverfasser: Tainer, John A., Roberts, Victoria A., Getzoff, Elizabeth D.
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Biotechnology
Computer Simulation
Metals - metabolism
Protein Conformation
Protein Engineering
Proteins - chemistry
Proteins - metabolism
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Beschreibung
Zusammenfassung:Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins. Recent developments have been made in the understanding and design of metal-binding sites in proteins, an important and rapidly advancing area of protein engineering.
ISSN:0958-1669
1879-0429
DOI:10.1016/0958-1669(92)90166-G