Inotropic influence of macrocyclic polyethers on tracheal smooth muscle

Incubated guinea pig tracheal smooth muscle exhibited both positive and negative inotropic responses to a variety of crown ether analogs that ranged in size from 12-crown-4 to 30-crown-10 and included molecules whose lipophilicity was modified by the addition of benzo- and cyclohexo- substituents on...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-08, Vol.42 (4), p.645-650
Hauptverfasser:	Kolbeck, Ralph C., La Neave, Cindy, Aguirre, Adela, Nosek, Thomas M., Pannell, Keith H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Crown ether ionophores effects on Ethers, Cyclic - pharmacology Guinea Pigs In Vitro Techniques inotropism Male Medical sciences Membrane physiology Muscle Contraction - drug effects Muscle, Smooth - drug effects Pharmacology. Drug treatments polyethers Respiratory system Smooth muscle Structure-Activity Relationship Trachea Trachea - drug effects
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Zusammenfassung:	Incubated guinea pig tracheal smooth muscle exhibited both positive and negative inotropic responses to a variety of crown ether analogs that ranged in size from 12-crown-4 to 30-crown-10 and included molecules whose lipophilicity was modified by the addition of benzo- and cyclohexo- substituents on the basic molecular framework. The inotropic influence of crown ethers may not only be due to their ionophoretic capabilities but may result from their ability to affect alterations in membrane physiology.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(92)90010-D