Binding of strychnocarpine and related β-carbolines to brain receptors in vitro

The affinity of strychnocarpine and related β-carbolines for serotonin, benzodiazepine, tryptamine, opiate and GABA receptors in rat brain was studied. Strychnocarpine showed a low to very low affinity for all the receptors tested. The weak binding to tryptamine receptors might explain part of the t...

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Veröffentlicht in:	European journal of pharmacology 1992-04, Vol.214 (2), p.165-168
Hauptverfasser:	Strömbom, Jan, Jokela, Reija, Saano, Veijo, Rolfsen, Wenche
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT (5-hydroxytryptamine, serotonin) analysis Animals Benzodiazepines beta -carbolines binding Biological and medical sciences brain Brain - metabolism Carbolines - chemistry Carbolines - metabolism GABA receptors in vitro In Vitro Techniques Kinetics Male Medical sciences Opiate receptors Plant poisons toxicology Rats Rats, Inbred Strains receptors Receptors, Cell Surface - metabolism Receptors, GABA-A - metabolism Receptors, Serotonin - metabolism Strychnocarpine Toxicology Tryptamine β-Carbolines
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