Binding of strychnocarpine and related β-carbolines to brain receptors in vitro

The affinity of strychnocarpine and related β-carbolines for serotonin, benzodiazepine, tryptamine, opiate and GABA receptors in rat brain was studied. Strychnocarpine showed a low to very low affinity for all the receptors tested. The weak binding to tryptamine receptors might explain part of the t...

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Veröffentlicht in:	European journal of pharmacology 1992-04, Vol.214 (2), p.165-168
Hauptverfasser:	Strömbom, Jan, Jokela, Reija, Saano, Veijo, Rolfsen, Wenche
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT (5-hydroxytryptamine, serotonin) analysis Animals Benzodiazepines beta -carbolines binding Biological and medical sciences brain Brain - metabolism Carbolines - chemistry Carbolines - metabolism GABA receptors in vitro In Vitro Techniques Kinetics Male Medical sciences Opiate receptors Plant poisons toxicology Rats Rats, Inbred Strains receptors Receptors, Cell Surface - metabolism Receptors, GABA-A - metabolism Receptors, Serotonin - metabolism Strychnocarpine Toxicology Tryptamine β-Carbolines
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Zusammenfassung:	The affinity of strychnocarpine and related β-carbolines for serotonin, benzodiazepine, tryptamine, opiate and GABA receptors in rat brain was studied. Strychnocarpine showed a low to very low affinity for all the receptors tested. The weak binding to tryptamine receptors might explain part of the tremorigenic effects found earlier in the in vivo studies.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90114-J