Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51
We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. This finding suggests that may be a genetic predisposition for “idiopathic” childhood stroke, and host factors, possibly in concert with en...
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| Veröffentlicht in: | Annals of neurology 1992-06, Vol.31 (6), p.675-677 |
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| container_end_page | 677 |
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| container_issue | 6 |
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| container_title | Annals of neurology |
| container_volume | 31 |
| creator | Mintz, Mark Epstein, Leon G. Koenigsberger, M. Richard |
| description | We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. This finding suggests that may be a genetic predisposition for “idiopathic” childhood stroke, and host factors, possibly in concert with environmental factors or viruses, may play a major role in the mechanism of unexplained occlusion of the cerebral vasculature in children. |
| doi_str_mv | 10.1002/ana.410310618 |
| format | Article |
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Richard</creatorcontrib><title>Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. This finding suggests that may be a genetic predisposition for “idiopathic” childhood stroke, and host factors, possibly in concert with environmental factors or viruses, may play a major role in the mechanism of unexplained occlusion of the cerebral vasculature in children.</description><subject>Biological and medical sciences</subject><subject>Cerebrovascular Disorders - ethnology</subject><subject>Cerebrovascular Disorders - genetics</subject><subject>Cerebrovascular Disorders - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease Susceptibility - immunology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes, MHC Class I</subject><subject>Genetic Predisposition to Disease</subject><subject>Hispanic Americans - genetics</subject><subject>HLA-B Antigens - analysis</subject><subject>HLA-B51 Antigen</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Vascular Diseases - genetics</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1r20AQxZfQkrpujzkG9lBCe1C6o_2QdLRDvsCkoaQkt2W8GlVby1pHK5H4v6-KjdtTYWAO85s3bx5jJyDOQYj0K7Z4rkBIEAbyIzYBLSHJU1W8YRMhjUo0SPWOvY_xlxCiMCCO2TFoUFkuJuz-tvRhg33tHXe1b8o6hJLHvgsr4j5yjDE4jz2V_MX3Na-HNba8oWEV3LYnjm3vf1LLP98sZl-SuYYP7G2FTaSP-z5lP64uHy5uksW369uL2SJxSsg8MVlZQFnpCkS-zKVEMkoXpEyqHeocUtTaQSqAdLY0ReqkqcigIuNcXgLKKTvb6W668DxQ7O3aR0dNgy2FIdpMghaQyRFMdqDrQowdVXbT-TV2WwvC_knQjgnaQ4Ijf7oXHpZrKv_Su8jG-af9HKPDpuqwdT4eMD2-IMeasmyHvfiGtv-_aWd3s38N7A372NPrYRO7lTWZzLR9vLu2T3D_-PBdz62WvwHr8ZZC</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>Mintz, Mark</creator><creator>Epstein, Leon G.</creator><creator>Koenigsberger, M. 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Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4038-67d91df5f108b833ae6459e4625ca5812a55c1201e57b692c36fe6a4e6cc8d1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Cerebrovascular Disorders - ethnology</topic><topic>Cerebrovascular Disorders - genetics</topic><topic>Cerebrovascular Disorders - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Susceptibility - immunology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes, MHC Class I</topic><topic>Genetic Predisposition to Disease</topic><topic>Hispanic Americans - genetics</topic><topic>HLA-B Antigens - analysis</topic><topic>HLA-B51 Antigen</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Vascular Diseases - genetics</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mintz, Mark</creatorcontrib><creatorcontrib>Epstein, Leon G.</creatorcontrib><creatorcontrib>Koenigsberger, M. 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Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1992-06</date><risdate>1992</risdate><volume>31</volume><issue>6</issue><spage>675</spage><epage>677</epage><pages>675-677</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. 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| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 1992-06, Vol.31 (6), p.675-677 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Cerebrovascular Disorders - ethnology Cerebrovascular Disorders - genetics Cerebrovascular Disorders - immunology Child Child, Preschool Disease Susceptibility - immunology Female Gene Frequency Genes, MHC Class I Genetic Predisposition to Disease Hispanic Americans - genetics HLA-B Antigens - analysis HLA-B51 Antigen Humans Infant Male Medical sciences Neurology Vascular Diseases - genetics Vascular diseases and vascular malformations of the nervous system |
| title | Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51 |
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