Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51

We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. This finding suggests that may be a genetic predisposition for “idiopathic” childhood stroke, and host factors, possibly in concert with en...

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Veröffentlicht in:	Annals of neurology 1992-06, Vol.31 (6), p.675-677
Hauptverfasser:	Mintz, Mark, Epstein, Leon G., Koenigsberger, M. Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cerebrovascular Disorders - ethnology Cerebrovascular Disorders - genetics Cerebrovascular Disorders - immunology Child Child, Preschool Disease Susceptibility - immunology Female Gene Frequency Genes, MHC Class I Genetic Predisposition to Disease Hispanic Americans - genetics HLA-B Antigens - analysis HLA-B51 Antigen Humans Infant Male Medical sciences Neurology Vascular Diseases - genetics Vascular diseases and vascular malformations of the nervous system
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Beschreibung
Zusammenfassung:	We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA‐B51 in common. This finding suggests that may be a genetic predisposition for “idiopathic” childhood stroke, and host factors, possibly in concert with environmental factors or viruses, may play a major role in the mechanism of unexplained occlusion of the cerebral vasculature in children.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410310618