Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry

ESI mass spectra show that up to five ruthenium molecules can bind non-covalently to double stranded 16mer DNA, and provide information on the relative affinity and DNA sequence selectivity of different ruthenium complexes.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2003-03 (5), p.626-627
Hauptverfasser:	Beck, Jennifer L, Gupta, Rajesh, Urathamakul, Thitima, Williamson, Nyree L, Sheil, Margaret M, Aldrich-Wright, Janice R, Ralph, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - chemistry DNA - metabolism Intercalating Agents - chemistry Intercalating Agents - metabolism Oligonucleotides - chemistry Oligonucleotides - metabolism Organometallic Compounds - chemistry Organometallic Compounds - metabolism Ruthenium - chemistry Ruthenium - metabolism Spectrometry, Mass, Electrospray Ionization Substrate Specificity
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Beschreibung
Zusammenfassung:	ESI mass spectra show that up to five ruthenium molecules can bind non-covalently to double stranded 16mer DNA, and provide information on the relative affinity and DNA sequence selectivity of different ruthenium complexes.
ISSN:	1359-7345
DOI:	10.1039/b212132h