The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I

The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I

The tetranucleotide repeat locus C2_4_4 situated in the HLA class I region (6p21.3) and the HLA-ABC specificities were investigated in an Austrian population sample of 240 unrelated Caucasoid individuals. The analysis of the linkage disequilibrium between C2_4_4 and HLA class I showed several signif...

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Veröffentlicht in:Immunobiology (1979) 2003, Vol.207 (2), p.137-140
Hauptverfasser: Stadlbacher, Simone, Dauber, Eva-Maria, Wenda, Sabine, Glock, Barbara, Hafner, Maria, Körmöczi, Günther F., Mayr, Wolfgang R.
Format: Artikel
Sprache:eng
Schlagworte:
Austria
Gene Frequency
Genes, MHC Class I
Humans
Linkage Disequilibrium
Microsatellite Repeats - genetics
Polymorphism, Genetic
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Zusammenfassung:The tetranucleotide repeat locus C2_4_4 situated in the HLA class I region (6p21.3) and the HLA-ABC specificities were investigated in an Austrian population sample of 240 unrelated Caucasoid individuals. The analysis of the linkage disequilibrium between C2_4_4 and HLA class I showed several significant values, especially when factors coded for by so-called “superhaplotypes” were considered; such linkage disequilibria are of importance for the practical use of HLA coded short tandem repeats.
ISSN:0171-2985
1878-3279
DOI:10.1078/0171-2985-00225