Regulation of inflammation by lipocortin 1

The mechanisms that regulate inflammatory responses, and their dysfunction in chronic inflammatory diseases, are poorly understood. Lipocortin 1 is a potential mediator of the anti-inflammatory effects of glucocorticoid hormones. Following the discovery of putative receptors on phagocytes for lipoco...

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Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1992-08, Vol.13 (8), p.295-297
Hauptverfasser:	Goulding, N.J, Guyre, P.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexins Biological and medical sciences Calcium-Binding Proteins - immunology Chronic Disease Disease Models, Animal Fundamental and applied biological sciences. Psychology Glucocorticoids - immunology Humans Inflammation Inflammation - immunology Molecular and cellular biology Monocytes - immunology Neutrophils - immunology Phagocytes - immunology
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Beschreibung
Zusammenfassung:	The mechanisms that regulate inflammatory responses, and their dysfunction in chronic inflammatory diseases, are poorly understood. Lipocortin 1 is a potential mediator of the anti-inflammatory effects of glucocorticoid hormones. Following the discovery of putative receptors on phagocytes for lipocortin 1, Nick Goulding and Paul Guyre here offer one explanation for the self-limitation of inflammation and the impairment of the mechanism in chronic inflammatory disease.
ISSN:	0167-5699
DOI:	10.1016/0167-5699(92)90040-E