Mammalian artificial chromosomes

Mammalian artificial chromosomes

A mammalian artificial chromosome would enable analysis of the cis-acting DNA sequences necessary for mammalian chromosome function and would allow large numbers of genes in a defined sequence environment to be introduced into experimental animals, agricultural livestock or human cells. Recent techn...

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Veröffentlicht in:Current opinion in genetics & development 1992-01, Vol.2 (3), p.479-486
1. Verfasser: Brown, William R.A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Biology
Centromere - physiology
Chromosomes - physiology
Chromosomes, Fungal
Genes, Synthetic - physiology
Genetics & Heredity
Humans
Life Sciences & Biomedicine
Mammals
Science & Technology
Telomere - physiology
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Beschreibung
Zusammenfassung:A mammalian artificial chromosome would enable analysis of the cis-acting DNA sequences necessary for mammalian chromosome function and would allow large numbers of genes in a defined sequence environment to be introduced into experimental animals, agricultural livestock or human cells. Recent technical progress suggests that a route to mammalian artifical chromosome construction is now open.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(05)80161-3