Enantioresolution and absolute configurations of chiral meta-substituted diphenylmethanols as determined by x-ray crystallographic and 1H NMR anisotropy methods

Enantioresolution and absolute configurations of chiral meta-substituted diphenylmethanols as determined by x-ray crystallographic and 1H NMR anisotropy methods

meta‐Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X‐ray crystallography of chiral phthalate esters and/or by the 1H NMR anisotropy method using 2‐methoxy‐2‐(1‐nap...

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Veröffentlicht in:Chirality (New York, N.Y.) N.Y.), 2003-05, Vol.15 (4), p.324-328
Hauptverfasser: Kosaka, Masashi, Sugito, Takeo, Kasai, Yusuke, Kuwahara, Shunsuke, Watanabe, Masataka, Harada, Nobuyuki, Job, Gabriel E., Shvet, Alex, Pirkle, William H.
Format: Artikel
Sprache:eng
Schlagworte:
2-methoxy-2-(1-naphthyl)propionic acid
chiral derivatizing agent
chiral phthalic acid
diastereomeric esters
HPLC separation on silica gel
internal standard of absolute configuration
MαNP acid
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Zusammenfassung:meta‐Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X‐ray crystallography of chiral phthalate esters and/or by the 1H NMR anisotropy method using 2‐methoxy‐2‐(1‐naphthyl)propionic acid. Chirality 15:324–328, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.10209