Fragmentation studies of peptides: The formation of Y ions

The mechanism for the formation of y ions in the collision‐induced dissociation (CID) spectra of protonated peptides produced by fast‐atom bombardment was investigated by tandem mass spectrometry and deuterium labelling studies. The results show that a hydrogen atom attached to nitrogen and not to c...

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Veröffentlicht in:	Rapid communications in mass spectrometry 1992-02, Vol.6 (2), p.95-97
Hauptverfasser:	Kenny, Peter T. M., Nomoto, Kyosuke, Orlando, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chemistry Disaccharides - genetics Exact sciences and technology Ions Mass spectrometry Molecular Sequence Data Organic chemistry Peptides - genetics Reactivity and mechanisms Spectrometry, Mass, Fast Atom Bombardment Urea - analogs & derivatives
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Beschreibung
Zusammenfassung:	The mechanism for the formation of y ions in the collision‐induced dissociation (CID) spectra of protonated peptides produced by fast‐atom bombardment was investigated by tandem mass spectrometry and deuterium labelling studies. The results show that a hydrogen atom attached to nitrogen and not to carbon migrates during cleavage of the amide bond. A mechanism based on these results is presented.
ISSN:	0951-4198 1097-0231
DOI:	10.1002/rcm.1290060205