Role of Plasminogen-Activator Inhibitor Type 1 in the Pathogenesis and Outcome of the Hemolytic Uremic Syndrome

THE hemolytic uremic syndrome is an important cause of acute and often of end-stage renal failure in children. 1 The disease is characterized by glomerular fibrin deposition. An intrinsic glomerular fibrinolytic mechanism mediated by tissue plasminogen activator and urokinase may play a part in the removal of such deposits. 2 In 1982, we described an inhibitor of glomerular fibrinolysis found in plasma from 17 children with the hemolytic uremic syndrome. 3 Although no correlation was found between the titer of inhibitor and the hematocrit, the white-cell and platelet counts, the serum creatinine concentrations, or the antiplasmin level, there was a close correlation between . . .