Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer

The effects of 12 weeks of ω-3 fatty acid supplementation on rectal mucosal proliferation were assessed with [3H]thymidine autoradiography in a double-blind, placebo-controlled study of 20 patients with sporadic adenomatous colorectal polyps. In the group of 10 that received fish oil containing eico...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1992-09, Vol.103 (3), p.883-891
Hauptverfasser: Anti, Marcello, Marra, Giancarlo, Armelao, Franco, Bartoli, Gianna Maria, Ficarelli, Rita, Percesepe, Antonio, De Vitis, Italo, Maria, Giorgio, Sofo, Luigi, Rapaccini, Gian Ludovico, Gentiloni, Nicola, Piccioni, Elisabetta, Miggiano, Giacinto
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Sprache:eng
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Zusammenfassung:The effects of 12 weeks of ω-3 fatty acid supplementation on rectal mucosal proliferation were assessed with [3H]thymidine autoradiography in a double-blind, placebo-controlled study of 20 patients with sporadic adenomatous colorectal polyps. In the group of 10 that received fish oil containing eicosapentaenoic acid (4.1 g/day) and docosahexaenoic acid (3.6 g/day), the mean percentage of replicative “S”-phase cells in the upper part of colonic crypts (considered a reliable marker of colon cancer risk) significantly dropped from the baseline level after only 2 weeks of treatment and remained lower throughout the study period; no change in upper-crypt labeling was observed in the 10 placebo patients. Rectal mucosal eicosapentaenoic acid content increased in fish oil patients, whereas arachidonic acid levels decreased. The fish oil-induced kinetic changes represent contraction of the proliferative compartment to the levels of a low-risk population and may be related to ω-3 fatty acid effects on the arachidonic prostaglandin pathway. In this short-term trial, fish oil appeared to exert a rapid effect that may protect high-risk subjects from colon cancer.
ISSN:0016-5085
1528-0012
DOI:10.1016/0016-5085(92)90021-P