PI-200 AND PI-201, NEW PLATELET AGGREGATION INHIBITORS PRODUCED BY Streptomyces sp. A7498: TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 × 10-4M and 7.1 × 10-4M, respectively.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1992/06/25, Vol.45(6), pp.892-898
Hauptverfasser:	KISHIMURA, YUKO, KAWASHIMA, AKIRA, KAGAMIZONO, TERUMI, YAMAGISHI, MICHIO, MATSUMOTO, KEITA, KAWASHIMA, YUTAKA, HANADA, KAZUNORI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology Microbiology Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Phenanthrenes - isolation & purification Phenanthrenes - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - isolation & purification Platelet Aggregation Inhibitors - pharmacology Rabbits Streptomyces Streptomyces - classification Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 × 10-4M and 7.1 × 10-4M, respectively.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.892