Platelet-activating factor acetylhydrolase is increased in lung lavage fluid from patients with acute respiratory distress syndrome

OBJECTIVEPlatelet-activating factor (PAF) is a proinflammatory phospholipid that may contribute to inflammation in the acute respiratory distress syndrome (ARDS). PAF acetylhydrolase (PAF-AH) degrades PAF and regulates its biological activity. We characterized PAF-AH in bronchoalveolar lavage fluid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Critical care medicine 2003-03, Vol.31 (3), p.770-775
Hauptverfasser:	Grissom, Colin K, Orme, James F, Richer, Lori D, McIntyre, Thomas M, Zimmerman, Guy A, Elstad, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Bronchoscopy Case-Control Studies Disease Progression Emergency and intensive respiratory care Female Humans Inflammation Intensive care medicine Macrophages, Alveolar - immunology Macrophages, Alveolar - secretion Male Medical sciences Middle Aged Phospholipases A - analysis Phospholipases A - genetics Phospholipases A - immunology Respiratory Distress Syndrome, Adult - enzymology Respiratory Distress Syndrome, Adult - immunology Respiratory Distress Syndrome, Adult - mortality Respiratory Distress Syndrome, Adult - pathology Risk Factors RNA, Messenger - analysis Survival Analysis Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	OBJECTIVEPlatelet-activating factor (PAF) is a proinflammatory phospholipid that may contribute to inflammation in the acute respiratory distress syndrome (ARDS). PAF acetylhydrolase (PAF-AH) degrades PAF and regulates its biological activity. We characterized PAF-AH in bronchoalveolar lavage fluid from ARDS patients (n = 33, 22 survivors), patients at risk for ARDS (n = 6), and healthy controls (n = 6). DESIGNBronchoalveolar lavage was performed during acute (
ISSN:	0090-3493 1530-0293
DOI:	10.1097/01.CCM.0000053647.82608.29