Human Immunodeficiency Virus Type 1-Related Lipoatrophy and Lipohypertrophy Are Associated with Serum Concentrations of Leptin
The relationship between the adipocyte-derived hormone leptin, insulin resistance, and fat redistribution in patients with human immunodeficiency virus (HIV) infection has not been established. We classified a cohort of HIV type 1 (HIV-1)-infected patients with ∼6 months of antiretroviral exposure a...
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Veröffentlicht in: | Clinical infectious diseases 2003-03, Vol.36 (6), p.795-802 |
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Sprache: | eng |
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Zusammenfassung: | The relationship between the adipocyte-derived hormone leptin, insulin resistance, and fat redistribution in patients with human immunodeficiency virus (HIV) infection has not been established. We classified a cohort of HIV type 1 (HIV-1)-infected patients with ∼6 months of antiretroviral exposure as having no lipodystrophy (51 patients [43% of the cohort]), lipoatrophy (23 patients [19% of the cohort]), mixed lipodystrophy (29 patients [24% of the cohort]), or lipohypertrophy (17 patients [14% of the cohort]), on the basis of physical examination, anthropometric measurements, and the findings of dual-emission x-ray absorptiometry and computed tomography. Measurements of insulin resistance were higher for patients with each category of lipodystrophy, compared with those observed for patients with no lipodystrophy (P |
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ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/367859 |