Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial

Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial

Background The treatment of distal ulcerative colitis, refractory to conventional 5‐ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5‐ASA in the treatment of th...

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Veröffentlicht in:European journal of clinical investigation 2003-03, Vol.33 (3), p.244-248
Hauptverfasser: Vernia, P., Annese, V., Bresci, G., D'Albasio, G., D'Incà, R., Giaccari, S., Ingrosso, M., Mansi, C., Riegler, G., Valpiani, D., Caprilli, R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Anti-Ulcer Agents - therapeutic use
Butyrate
Butyrates - therapeutic use
Chronic Disease
clinical trial
Colitis, Ulcerative - drug therapy
Double-Blind Method
Drug Therapy, Combination
Female
Humans
inflammatory bowel disease
Male
Mesalamine - therapeutic use
Middle Aged
refractory ulcerative colitis
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Zusammenfassung:Background The treatment of distal ulcerative colitis, refractory to conventional 5‐ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5‐ASA in the treatment of this condition. Design Double‐blind, placebo‐controlled, multicentre study. A total of 51 patients with distal (
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.2003.01130.x