Effect of Ha-ras on mitogen-induced Ca(2+)- and K(+)-fluxes

Effect of Ha-ras on mitogen-induced Ca(2+)- and K(+)-fluxes

Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.

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Bibliographische Detailangaben
Veröffentlicht in:Advances in enzyme regulation 1992, Vol.32, p.163-176
Hauptverfasser: Grunicke, H, Maly, K, Meyer, M, Oberhuber, H, Bichler, I, Waldegger, L S, Woell, E, Lang, F
Format: Artikel
Sprache:eng
Schlagworte:
3T3 Cells
Animals
Biological Transport, Active - drug effects
Bombesin - pharmacology
Bradykinin - pharmacology
Calcium - metabolism
Cell Division - drug effects
Fibroblasts
Furosemide - pharmacology
Mice
Mitogens - pharmacology
Oncogene Protein p21(ras) - pharmacology
Potassium - metabolism
Rubidium - metabolism
Transfection
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Zusammenfassung:Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.
ISSN:0065-2571
DOI:10.1016/0065-2571(92)90015-R