Synthesis and preliminary biological evaluation of 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT

Novel radiolabeled O 6-benzylguanine derivatives, 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines ([ 11C] p- O 6-MMBG, 1a; [ 11C] m- O 6-MMBG, 1b; ([ 11C] o- O 6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repai...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-02, Vol.13 (4), p.641-644
Hauptverfasser:	Liu, Xuan, Zheng, Qi-Huang, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W, Erickson, Leonard C, Stone, K.Lee, Hutchins, Gary D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Cell Line, Tumor Contrast media. Radiopharmaceuticals Enzyme Inhibitors - chemical synthesis Guanine - analogs & derivatives Guanine - chemical synthesis Humans Medical sciences O-Methylguanine-DNA Methyltransferase - antagonists & inhibitors O-Methylguanine-DNA Methyltransferase - metabolism Pharmacology. Drug treatments Protein Binding Structure-Activity Relationship Tomography, Emission-Computed - methods
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Zusammenfassung:	Novel radiolabeled O 6-benzylguanine derivatives, 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines ([ 11C] p- O 6-MMBG, 1a; [ 11C] m- O 6-MMBG, 1b; ([ 11C] o- O 6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O 6-alkylguanine-DNA alkyltransferase (AGT). Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)01048-X