Spontaneous conversion of PrPC to PrPSc

Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals...

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Veröffentlicht in:	FEBS letters 1992-07, Vol.307 (2), p.129-130
1. Verfasser:	Sulkowski, Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Conformational isoform Conversion of PrPC to PrPSc Fundamental and applied biological sciences. Psychology Humans Interactions. Associations Intermolecular phenomena Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Metals - metabolism Molecular biophysics Prion disease Prion protein Prions - chemistry Prions - metabolism Protein Conformation PrPSc Proteins Transition metal
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