Spontaneous conversion of PrPC to PrPSc

Spontaneous conversion of PrPC to PrPSc

Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals...

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Bibliographische Detailangaben
Veröffentlicht in:FEBS letters 1992-07, Vol.307 (2), p.129-130
1. Verfasser: Sulkowski, Eugene
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Conformational isoform
Conversion of PrPC to PrPSc
Fundamental and applied biological sciences. Psychology
Humans
Interactions. Associations
Intermolecular phenomena
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - metabolism
Metals - metabolism
Molecular biophysics
Prion disease
Prion protein
Prions - chemistry
Prions - metabolism
Protein Conformation
PrPSc Proteins
Transition metal
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Beschreibung
Zusammenfassung:Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)80750-B