Spontaneous conversion of PrPC to PrPSc
Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals...
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| Veröffentlicht in: | FEBS letters 1992-07, Vol.307 (2), p.129-130 |
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| container_title | FEBS letters |
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| creator | Sulkowski, Eugene |
| description | Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals. |
| doi_str_mv | 10.1016/0014-5793(92)80750-B |
| format | Article |
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It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be triggered by the coordination of these metals.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conformational isoform</subject><subject>Conversion of PrPC to PrPSc</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Interactions. Associations</subject><subject>Intermolecular phenomena</subject><subject>Membrane Glycoproteins - chemistry</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Metals - metabolism</subject><subject>Molecular biophysics</subject><subject>Prion disease</subject><subject>Prion protein</subject><subject>Prions - chemistry</subject><subject>Prions - metabolism</subject><subject>Protein Conformation</subject><subject>PrPSc Proteins</subject><subject>Transition metal</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF9LwzAUxYMoc06_gUIfxD8P1ZukXZLHdWwqDBxMn0OaJlDpmtpsyr69zVbm0-Xe8-Peew5C1xieMODxMwBO4pQJ-iDIIweWQpydoCHmjMY0GfNTNDwi5-jC-y_oeo7FAA0wTSkjbIjuV42rN6o2busj7eof0_rS1ZGz0bJdTqONC3WlL9GZVZU3V30doc_57GP6Gi_eX96mk0XcYIGzOE1IblViCQPNlDaEcGuE0jjPGQDFCrhVgG1SFJQqqjjjmptCMcKNtRTTEbo77G1a9701fiPXpdemqg4vSkY775BAB9704DZfm0I2bblW7U72zjr9tteV16qyrap16Y9YSgVPcLg3P2C_ZWV2_1tAhoxlCFCGAKUgcp-xzOR8lpEghLkg-2lG_wBHF29E</recordid><startdate>19920728</startdate><enddate>19920728</enddate><creator>Sulkowski, Eugene</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19920728</creationdate><title>Spontaneous conversion of PrPC to PrPSc</title><author>Sulkowski, Eugene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p191B-542bfa4f270c7ace228fe9ac1bb70031a08fa01f4dd33a3a878c8eda728eff313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conformational isoform</topic><topic>Conversion of PrPC to PrPSc</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Interactions. Associations</topic><topic>Intermolecular phenomena</topic><topic>Membrane Glycoproteins - chemistry</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Metals - metabolism</topic><topic>Molecular biophysics</topic><topic>Prion disease</topic><topic>Prion protein</topic><topic>Prions - chemistry</topic><topic>Prions - metabolism</topic><topic>Protein Conformation</topic><topic>PrPSc Proteins</topic><topic>Transition metal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sulkowski, Eugene</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sulkowski, Eugene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous conversion of PrPC to PrPSc</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1992-07-28</date><risdate>1992</risdate><volume>307</volume><issue>2</issue><spage>129</spage><epage>130</epage><pages>129-130</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Octa‐repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. 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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1992-07, Vol.307 (2), p.129-130 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73101040 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Conformational isoform Conversion of PrPC to PrPSc Fundamental and applied biological sciences. Psychology Humans Interactions. Associations Intermolecular phenomena Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Metals - metabolism Molecular biophysics Prion disease Prion protein Prions - chemistry Prions - metabolism Protein Conformation PrPSc Proteins Transition metal |
| title | Spontaneous conversion of PrPC to PrPSc |
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