Glucose Regulates Monocyte Adhesion Through Endothelial Production of Interleukin-8

ABSTRACT—We have shown that glucose increases monocyte adhesion to human aortic endothelial cells (HAECs) in vitro. In the present study, we examined mechanisms by which glucose stimulates monocyte:endothelial interactions. HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in int...

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Veröffentlicht in:	Circulation research 2003-03, Vol.92 (4), p.371-377
Hauptverfasser:	Srinivasan, Suseela, Yeh, Michael, Danziger, Eric C, Hatley, Melissa E, Riggan, Anna E, Leitinger, Norbert, Berliner, Judith A, Hedrick, Catherine C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Binding Sites - genetics Biological and medical sciences Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Cell Adhesion - drug effects Cell Adhesion - physiology Cells, Cultured Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Expression Regulation - drug effects Glucose - pharmacology Humans Interleukin-8 - biosynthesis Interleukin-8 - genetics Medical sciences Mice Mice, Inbred C57BL Mice, Obese Mitochondria - drug effects Mitochondria - metabolism Monocytes - cytology Monocytes - drug effects Promoter Regions, Genetic - genetics Reactive Oxygen Species - metabolism RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Thenoyltrifluoroacetone - pharmacology Transcription Factor AP-1 - metabolism Uncoupling Agents - pharmacology
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Zusammenfassung:	ABSTRACT—We have shown that glucose increases monocyte adhesion to human aortic endothelial cells (HAECs) in vitro. In the present study, we examined mechanisms by which glucose stimulates monocyte:endothelial interactions. HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in interleukin-8 (IL-8) secretion over control cells cultured in 5.5 mmol/L glucose (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.0000061714.74668.5C