Hibernating myocardium : a historical perspective

Hibernating myocardium refers to the presence of persistent myocardial and left ventricular dysfunction at rest, associated with conditions of severely reduced coronary blood flow. This left ventricular dysfunction probably represents an adaptive mechanism preventing irreversible myocardial cell dam...

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Veröffentlicht in:	Cardiovascular drugs and therapy 1992-06, Vol.6 (3), p.267-271
Hauptverfasser:	TUBAU, J. F, RAHIMTOOLA, S. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biological and medical sciences Cardiology. Vascular system Coronary Circulation Coronary Disease - metabolism Coronary Disease - physiopathology Coronary heart disease Down-Regulation Heart Heart - physiopathology Humans Medical sciences Myocardium - metabolism Ventricular Function, Left - physiology
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Beschreibung
Zusammenfassung:	Hibernating myocardium refers to the presence of persistent myocardial and left ventricular dysfunction at rest, associated with conditions of severely reduced coronary blood flow. This left ventricular dysfunction probably represents an adaptive mechanism preventing irreversible myocardial cell damage, since myocardial and left ventricular dysfunction in hibernating myocardium improve following the restoration of coronary blood flow. This review examines the evolution of the concept of hibernation from a clinical observation of the potential underlying mechanisms recently proposed.
ISSN:	0920-3206 1573-7241
DOI:	10.1007/BF00051149