Intermolecular cooperativity: a clue to why mice have IgG3?

Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens. The reasons for this isotype restriction are not fully understood. Here, Neil Greenspan and Laurence Cooper propose that intermolecular cooperativity, a novel mechanism of antibody binding, may help...

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Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1992, Vol.13 (5), p.164-168
Hauptverfasser:	Greenspan, Neil S, Cooper, Laurence J.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - immunology Antibodies, Bacterial - metabolism Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibody Affinity Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Immunoglobulin Fc Fragments - metabolism Immunoglobulin G - immunology Immunoglobulin G - metabolism Mice - immunology Models, Biological Molecular Structure Polysaccharides, Bacterial - immunology Polysaccharides, Bacterial - metabolism Protein Binding Protein Conformation Structure-Activity Relationship
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Zusammenfassung:	Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens. The reasons for this isotype restriction are not fully understood. Here, Neil Greenspan and Laurence Cooper propose that intermolecular cooperativity, a novel mechanism of antibody binding, may help to explain the preferential expression of IgG3 antibodies in these responses.
ISSN:	0167-5699
DOI:	10.1016/0167-5699(92)90120-V